375 is a medium bore, the 40's are large medium bores.....
375 H&H is the true all rounder legal and perfect for leopard and lion and well capable to deal with buff and the rest through to elephant and all the plains game in between.....not the caliber for the guide or PH to deal with follow ups....
So cats 375 H&H
Buffalo 404 or 416 ideal
Elephant min 458 but 500 is king...
My choices
375 H&H
404 Jeff
500/416 NE(buff or sorting out wounded lion)
500 Jeff sorting out buff and elephant when woundedI