@Philip Glass I agree with most of what you said, especially for a scoped 375 caliber bolt action rifle. All my newer scopes also have a red dot on the reticle. I have a Leupold VX6 2x-12 on my Whitworth Interarms Mauser. I find that 2x is low enough for lion, buffalo and other DG but I can crank it up for longer shots at PG. I have the same scope on my AHR CZ550 375 that I use for a client gun in Alaska.
On my AHR CZ550 458 Lott, I have a Leupold VX-R 2x-7 on it for use as my guiding gun for brown bear. For elephant with this same rifle, I have a Leica red dot sight that is sighted for 25 yards. I also have an “old school” Leupold VX3 1.5x-5 sighted at 25 yards for elephant. I also take all three of these optics with me to Alaska in case one fails or I have to track a wounded bear into heavy alders and decide to remove the scope to use the iron sights or the Leica red dot.
This is where I disagree with you concerning QD mounts. I have never had an issue with Talley QD rings not going back to zero or becoming loose. I finger tighten them and then use my Leatherman tool to tighten them another 1/8”. The CZ550 integral bridge and dovetail also helps prevent issues with returning to zero. I can develop different loads for the different scopes as well and easily switch the scope out for another scope/load. On my last several trips to Africa and Alaska after reattaching the scopes, I’ve only had to fire one shot each time to confirm zero with this system. I make sure to reattach the scope and turn the tightening levers exactly the same way each time. I tighten both levers evenly to where they just start to get snug. I then tighten the rear lever that is in the dovetail to full tightness before I fully tighten the front lever. This seems to work great.