Hello Bsums,
Regarding Malaria, I would recommend the fallowing :
1. Long trousers and long sleeves during the evenings.
2. Mosquito net over your bed, check so there is not any holes in the net.
3. Spray the room one hour before you go the sleep with RADAR or some other insecticide preparate.
4. Use "djungel oil" or some other anti mosquito preparate for your neck/ears/ankles/hands.
5. Now we come to the most important part : If you feel the slightest headache or freezing take 4 tablets Malarone at ones for 3 days, and you are cured, and the malaria will never brake out.
The other thing I think you have down there also Simon is the Tsetse Flies, the risk to get sleeping sickness is 1 of 5000 so the risk to get it it's very low... anyhow they get sometime nasty when they are hungry special if they get locked inside a bungalow for a day or two... bring a small bottle of surgery spirit, if you got bitten put some spirit on a cotton pad and clean the bite for 30 seconds, after that put on some antibiotic salve to avoid infection.
This is my personal opinion, because I know that some people is very sensitive for this kind of anti malaria medication, some clients get depressed and can not sleep, nightmares, headache, dizzy, no appetite, your skin can be extremely sensitive for sun and you easy more easy bad sunburn and it can destroy a hunting totally.
One other think is that if I client take some kind of blood thinner medication like Warafin most antimalarial preparate will change your INR level.
Best way is to avoid the mosquitoes as I describe above, and if you plan to take anti malaria medication try a month before you travel and see how you reacting on it.