If you research it, you'll find that those overbore calibers have seriously wounded more humans than animals.
Great PH stopping guns for those that can handle 'em. If you handle 'em too much, they will handle your musculature/nervous system/skeleton. No kidding. 'Have an old collection of Capstick hunting videos...there's a perfect slow-motion scene of him firing 2 shots at a huge Botswana bull elephant using a 577 (i know he liked 470 but I believe this to be true.) The muzzle blast, recoil and how it contorts his body upon pulling the trigger is quite astounding. Many have downgraded from those cannons. The same happens to archers that shoot 70+ lb bows on deer-sized game (when the 50-60ish lb models do just fine!) The price of ego, hormones and money. The swinging trunk club. All that said, many experienced hunters have settled on the .577 and claim that it's nothing like the punishment of a .600 or .700 (comparing it more to a .470-.500, which would be the top end of any big bore gun I'd shoot.) One of the first things I do when any new rifle gets set up, is that I go varmint hunting with it to practice shooting in the field. I wouldn't like to do that with a .600"+ although I might cause them to die of heart attacks or sudden extreme ear pressures...