To echo the points above, let me tell you an old fashioned African tradition.
As you all know, the 375HH is the most common African rifle ever made. Throughout the 1960s, the most useless, unreliable, underperforming factory ammo was the 375HH Winchester Silver Tip. The were just awful, except for one purpose.
Many, many PHs would hoard these old underperformers and would use a needle nose pliers to remove the silver tip from the bullets. The net result was making a sadly innaccurate, but very flimsy hollow point out of them. Those, they would use for leopards at 50 paces from a blind.
The moral of this old story is a simple one: For a leopard hunt using a medium or large bore, you need an awful bullet. In today's day, finding an awful bullet is a pretty hard thing to come across. A nosler ballistic tip, or a combined technologies winchester silver tip, or a Scirrocco, or a Speer Hot Core would be what I consider to be an awful bullet. That's what I'd shoot at a Leopard if I was really trying to ensure good expansion.
What did I use? A 375HH with a swift A-frame. Its what I had. It worked, it shattered bones and completely anchored the animal, but it was not a pleasant walk-up after the shot. Tooth and claw snarling, certain this was going to be the worst case scenario of a charge from a wounded cat. It was not, it was a paralyzed but not rapidly dying cat.
A lousy bullet would have made a swift end of the situation, but the A-frame is not a lousy bullet. In this situation, it was a very potent solid that created an undesirable, but ultimately successful situation.