I am with
@ActionBob on this discussion. Lots of folks offering advice with respect to the lethality of a .223 or shot placement who have never seen a member of the tiny ten much less hunted them. The problem is not lethality but the destructive expansion of a light fast moving bullet.
Secondly, as Stuart from
@Tally-Ho HUNTING SAFARIS notes most of the tiny ten are taken as targets of opportunity while hunting other more traditional plains game. A bullet like an A Frame from a 30-06 will often work so long as the shoulder bone structure isn't hit.
I know you have this all figured out, but a blue duiker or sunni are about the size of a small jackrabbit. Hit him in the shoulder and you will certainly kill him, but you will also ruin him as a mountable trophy. Shooting the animal behind the last rib with a heavy for caliber deep penetrating SP like an A Frame and it will pass through completely and still humanely and quickly kill such a small animal. The hunter also has an animal that can go to the taxidermist as opposed to the gut pile. That strikes me as more ethical course of action.
This is a really large blue duiker taken with
@spike.t and
@PeteG on Takeri. The rifle is a .275 firing the 170 gr Oryx. Note the bullet placement. No bones were struck, the duiker died in his tracks, and the bullet made a 7mm entry hole and 7.1mm exit hole. Most of the reminder of the tiny ten I have taken with 300 gr solids from a .375. Again never an issue. I did shoot a Steenbock frontally on one of my early hunts with a 250 gr partition from a .338. We did not even try to photograph the ensuing mess.
Back to the OP's original question. If your wife loves that rifle and has confidence in it, then you might try something like a 64 gr bullet designed for deer. Shot placement will need to be precise. That fast a bullet, even if heavy for caliber, will be very destructive if it hits the shoulder bone. Again at that speed, it could have an explosive effect on the stomach. I did see a civit hit at close range with a 67 gr 5.56 and the results were very destructive. I have not tried a solid from a .223 on any African game.
As others suggest, a great dedicated Tiny Ten choice would be a .22 Hornet.