I've seen multiple hunting video's of Cape Buffalo hunts. They have been shot with a multitude of calibres. Most shots were good, some not so much to the chagrin of the PH. Yes CB's are tough but any animal that wants to live can make things "interesting" no matter how well the shot was or how much "tonnage" it received. Agreed sometimes bigger is better but not always.
One of the guys I shoot with had the same situation happen to him. Swears he smoked a moose at about 300yds but it wouldn't go down. When they got up to it it was dead but propped up by a small tree that could not be seen from 300yds away even with a scope. It had 3 shots all within a 3" group, and all in the boiler room!
My north of the border brother,
Here is where I must disagree.
Bigger, badder, faster, stronger is BY FAR always better for killing anything and being a player in the NFL.
My personal opinion is that the 375 H&H might just be a bit underpowered for a few of the dangerous game animals. Hell! I believe that the 458 WM is at the bottom shelf of acceptability.
"If" I am up to it my next and last trip to the big A I will bring a 378 and the T-Rex or maybe the Over Kill.
By the way, "she who must be obeyed" has had some words of wisdom for me that sound like they came out of " One Flew Over The Coo-coos Nest" about me hunting in Africa.
"What do you want to do? Die over there?"
"If you die there, plan on staying cause I'm not coming to get you!"
Poor thing, my Norwegian Ice Princess is now about as sharp as a beach ball.