There is nothing that walks on earth that cannot be (legally and ethically) killed with the .375. Looking at the list of animals you posted, you can use 250 or 270 grain bullets and reach out to 300 yds for moose and bear, use 300 grain for grizzly and Africa. If you feel you must go bigger, you of course can but the .375 is more versatile for your list than the others. I can attest to its STOPPING power even on a charging elephant with proper shot placement. Good luck with your choice and glad you have joined!