I personally think Safari's will be minimally effected by all the factors you mention, as will most 'genuine' luxury stuff.
What (IMO) will be impacted is the aspirational, fake luxury stuff that young, poor people buy on credit to try and get laid. Apple products, fancy TVs, entry level luxury cars, Gucci, etc.
Why do I think that? Well, genuine luxury things like Safaris are generally bought by people who are both well off, and well into their middle age.
Look at this forum.
A sweeping, but accurate summation of the demographic here could be shared thusly; Male, 45-75, upper middle class. I'd say that sums up roughly 85% of all regular commenters.
There's some exceptions. I'm 29 for instance. But I'd be astonished if I wasn't in the lowest 5th percentile for age on this forum. The 45-75 range in my summary above most likely has more outliers who are older, than outliers who are younger.
Same with economic status. There's a few 'less well off' folks who worked really, really hard to afford their safaris, just as there's a smattering of 'very affluent' folks, but again, they're the exception, not the rule. I'd estimate that the number of people on this forum who DON'T have a six figure annual income is pretty small. Yet that's the top 25% of all Americans...
This demographic (fairly old, fairly well off) is almost entirely insulated from the factors you mention.
Car loans? Not a financial stressor. Probably they paid cash for their vehicle. If they do have a car loan, it's coming out of discretionary money and they've taken it due to attractive interest rates, not because they didn't have the cash to pay outright.
Student loans? Most here are old enough that they never had one, those that did, paid it off decades ago.
House affordability? At most they're paying a mortgage on a fixed rate, most have a fully paid off house which they bought for basically nothing in the '80's. Rising property values is for the most part a 'plus', property tax impact exempted of course.
For many, they're not going to care if the entire economy takes a dump. They're retired, not like they can get laid off, and whilst stock market performance might impact their retirement draw down, most have enough cash there to do some active management, so... eh.
Personally, I'd be a lot more worried about the impact to all-inclusive vacations to Disney World, or Florida, or Cancun, than I would be about Safaris. Not to mention base model BMW's, Gucci anything, Apple anything, maybe Rolexes.