As a client hunter myself, I've been enjoying the greatest success with the .375 Holland & Holland Magnum caliber ever since my first African safari to Kenya in 1974. Penetration is immense. Trajectory is extremely flat. Recoil is very very manageable. I have been successfully using it to take multiple heads of 4 members of the African Big over the years (barring rhinoceros which I have not yet had the good fortune to hunt). The only department where it falls short is for body shots on bull elephant.
It is also increbibly versatile. You can use it to hunt African plains game. You can use it to hunt the great bears, elk, moose & caribou in America & Canada. You can use it to hunt Sambar, scrub bulls, banteng & water buffalo in Australia. You can use it to hunt the antelopes of Central Asia. It's the Swiss army knife of rifle calibers. It's not over-gunned for any game on the planet and under-gunned for only 1 (and ever so slightly in that department). For a one-rifle safari to Africa, you can't pick a better choice.
I have been using .375 Holland & Holland Magnum rifles loaned to me by my white hunters throughout most of my African hunting life, but in recent years... I started using my son-in-law's Remington Model 700 Custom with an M-16 extractor fitted and a Timney trigger installed. It is serving us incredibly well. But amongst currently manufactured rifles in this caliber, the Winchester Model 70 Safari Express is very decent value for the money. On the second hand market, keep your eyes peeled for a BRNO ZKK-602 (preferably a pre 1974 variant with the little pop-up peep sight in the receiver).
Ballistically speaking, the .375 Ruger can do whatever the .375 Holland & Holland Magnum can do. In Africa, the ammunition for the Holland & Holland Magnum will be relatively easier to source than that of the Ruger.
View attachment 575404
View attachment 575431
View attachment 575430
View attachment 575429
View attachment 575428
View attachment 575424
View attachment 575418
View attachment 575417
View attachment 575416
View attachment 575415
View attachment 575414
View attachment 575413
View attachment 575412
View attachment 575411
View attachment 575410
View attachment 575409
View attachment 575408
View attachment 575407
View attachment 575406
View attachment 575405
View attachment 575403
View attachment 575402
I have hunted African dangerous game with other calibers too, over the years.
Such as .404 Jeffery
View attachment 575444
View attachment 575445
.458 Winchester Magnum
View attachment 575443
And .600 Nitro Express
View attachment 575446
But none match a .375 Holland & Holland Magnum in terms of versatility & practicality.