I'm not sure why you keep stating stats that are not relevant. I do not recall ever saying use a varmint bullet for larger game. Or a lighter for caliber bullet or a little bullet for bigger game.The amount of energy transferred to an animal doesn't kill it. The amount of energy used to cause mortal wounds, of the sort that destroy the heart or CNS, or the sort that cause them to bleed out, is what's important. I agree with you on the monos, and I'm not a fan for a number of reasons.
A 40 gr Varmageddon fired at 4000 fps from a 22-250 will absolutely dump all of its energy in a deer. But unless you shoot it in the head, you're probably just going to create a nasty wound that gets infected and kills the deer a week or 3 from now. Even at 100 yards, it still has what is considered sufficient energy (a little north of 1000 ft lbs) to kill a deer. What it clearly lacks is the capacity to penetrate to the vitals.
Yes, fragmenting bullets "dump all their energy," but I'm not sure how that's a positive. The fragmenting largely occurs at the point of impact. Because the pieces have less mass than an intact bullet, each of them lacks the momentum to penetrate deeply. The deeper the penetration, the more likely it is that more vital tissue will be destroyed. This is one case where the whole is greater than the sum of its parts.
Instead of a single, large wound channel, you end up with a bunch of smaller, shallower wound channels that ultimately only damage flesh, not vitals. If there is wasted energy, it is all of those small fragments which fail to reach the vitals. They do not penetrate as deeply precisely because they lack the energy to overcome the resistance of the flesh.
I'm not saying cup-and-cores do not work. They clearly do. But there are better choices today, just as cup-and-cores were a better choice a century ago.
That said I have read many reports of zebra being killed with a 22 hornet, black bear killer with a 22mag. Also know of animals as large as horses to fall to a 204 ruger. I'm not condoning this just starting reports I have read and thing I have seen.
I'm not sure if you read the report that Hogpatrol post. It does a much better job of explaining things I have witnessed. Having cleaned many animals, the blood pressure spikes that he talks about makes sense. Having seen the blood vessels in the skin it makes perfect sense. I never gave it much thought as to why it worked I just seen the results and never seen a reason to change.
I guees at the end of the day all I'm asking, if you are going to disprove what I'm saying, disprove it in an apples to apples comparison. Not in a way that favors one side more than the other . I have started real world experiences and results with different bullets construction out of the same gun.