This June we brought two R8’s with .375, 9.3x62 and .270 Win barrels in one small case. I also brought a left handed bolt for my sister.
I hunted Dik Dik and Cape Buffalo with the .375. The 9.3 was for my daughter to hunt hippo.
I own and use the .22LR barrel regularly for shooting practice and small game hunting. It is a great advantage to be able to get a variety of calibers, but I’d recommend having a bigger caliber for Africa. Invariably, while hunting Dukier, you will see a nice animal in a much bigger species.
Note: I brought the two stocks and 3 barrels in my case under my name. The case was about 44 lbs. The scopes went in my carry on. So… you could go 3 barrels, but you might never use the others after you get on a roll with the .375.