I've had mostly positive results with Barnes TSX bullets.
As a deer/medium game bullet, I've had nothing but positive results. At the velocities typical of most long range deer loads, and the smaller size of such animals, you will get great penetration and expansion.
As a larger game bullet, in 375 Caliber, I have had the following results.
3- Australian Water Buffalo. 300 grain TSX bullets. Velocity 2450 FPS. Shot distance 50-100 yards. All full frontal shots, bullets penetrated to the vitals each time and the buffalo were dead on their feet. I, of course, kept shooting until they were down, but doubt it was needed.
1- Lioness. 270 Gr TSX. Velocity 2750 FPS. Shot distance 30 yards.
Shot her 5 times before she quit. Three shots were broadside into rib cage. One shot into the shoulder from the front. One shot into front leg just below the shoulder, while she was jumping around.
Some of the bullets penetrated completely, but two bullets blew completely apart and lost all pedals.
1- Cape Buffalo. 300 gr TSX. Velocity 2540 FPS. Shot distance 40 yards. First shot was angling forward from the last rib. The bullet penetrated through the left lung and was never recovered in the front shoulders. Very good penetration. The left lung was damaged very badly. Unfortunately, one lung isn't enough to slow them down much. Tracked him over 5 miles before catching up to him. Shot him again in the brisket. Limb deflected the bullet, so not sure if it hit straight or not, but there was an oblong hole completely through the brisket and out the other side. PH then shot the bull in the head with a 470 Double. Read my hunt report "Buffalo Rodeo In The Kalahari for details.
1- Eland 270 gr TSX. Velocity 2750 FPS. Shot distance 260 yards. Complete penetration through shoulder and out the ribcage on the opposite side. Bull ran 40 yards and collapsed.
TBC