Sure, you can shoot buffaloes with the cartridge 10,75x68.
I have shot three myself, two of them with original ammo from RWS and the classic 22,5g thin jacketed FMJ bullet. There were no problems, but don't make a mistake, the cartridge 10,75x68 is marginal for the purpose, no matter the bullet, and has no reserves. Everyone can read why in papers or on Forums.
I have also shot buffaloes with variant cartridges, some with smaller calibers like the 9,3x74R and 375 H&H Magnum, but other with much bigger calibers, including cartridges like the 416 Rem Mag, 11,2x72 Schüler or 12,7x70 Schüler, and especially about fifteen buffaloes with the cartridge 460 WBY-Magnum. That's why I have the feeling that some cartridges work better than the others. The cartridge 10,75x68 would therefore not be my first choice for hunting buffaloes, especially at a time when we have so many good Big Game cartridges available.
In the old days not every hunter in Africa had the opportunity or the money to get a suitable weapon and therefore had to make compromises. That is no longer the case for us nowadays, and we also have experiences after more than a hundred years of Big Game hunting in Africa and Asia that we can fall back, something that our predecessors could not do yet.