Talking from my own experience at age 64 and having hunted over 30 game species in Africa alone including several elephants and buffalo. I own a 9,3x74R double which is basically the ballistic twin. I would not hesitate to use it on any plains game. I have not used it on buffalo, but I was in camp with two other hunters with 9.3's and they both killed buffalo with out any trouble. One hunter was a expert and killed many buffalo and just wanted to try out this caliber for the first time 9.3x74R and the other hunter was a first timer with a 9.3x62, an older man but he got the job done too. Most of the African game I've shot was with a 375 H&H but I have also use 416 Rigby, 450/400 3" Nitro Express, 460 Wby Mag, .500 Jeffery, .500 Nitro Express and a 300 Win Mag, well I did do one handgun hunt with a 7mm TCU and killed a Kudu with it. I have shot 5 buffalo , 2 were frontal shots one with a .416 Rigby I had hand loaded 400gr Barnes TTS at 2550 FPS the bullet went through him lengthwise and found fully mushroomed under the skin of his hind quarter, he took 2 steps and gave me a broad side shot so I put a solid through his shoulders and he went down. The other frontal shot was with a 375 H&H and a 300 gr Swift A-Frame, dead center of his heart from the front he went about 75 yards. Shot a another buffalo the same day with a 450/400 double , broadside smashed his shoulder and he went about 75 yards too. I've shot other Buffalo with the 375 H&H and also a 460 Wby Mag. I do feel that the 9.3 and the 375 H&H do work OK on buffalo but I think the .416 is the ideal buffalo caliber. You spend a lot of hard earned money to hunt Africa and if you are only going once or maybe just a few times and dangerous game is on your list, then I would prefer to use a .416 or nothing smaller then a 375 H&H. The 9.3 will do the job of Buffalo but it's a slim margin for error. I don't think a quartering shot with a 9.3 would be wise unless you were using solids and then ?? But I think the 9.3 is fine for the biggest plains game except Giraffe unless you use solids. They have an incredible thick hide over 2" thick, even my 419 loaded with 400 gr Barnes TTS would not exit a broadside shot. If you are talking elephants, well I have only shot 2, one frontal brain shot and one hart shot. Both with a .500. I missed the brain with the first shot but that 570 gr solid transferred enough energy where it knocked him down and I was able to get in a follow up shot as he was starting to get back on his feet, had that been a 9,3 or 375, he may have been lost. The other elephant was hart shot and he dropped to his knees, got up and went about 30 yards. I don't think a 9.3 could have done that either.