Rick Cox,
Yes, my wife and I have worked through this in detail because we needed to make a personal decision.
She wanted a rifle for Tanzania, having a 270 for US hunting. She looked at the 338WM, 9.3x62, and 375(s). Because of legalities, the 375 won out even though she doesn't plan on chasing buffalo at the moment. She is fairly light in weight, medium height, so the 20" Ruger Alaskan with a shortened stock appealed to her. It is 9.0-9.5 pounds with a scope and comes in a 375 Ruger caliber. She has both 200grain GSC and 250TTSX loads available at 3100fps and 2815fps, respectively. It is a compact package that fits her better than a big lumbering CZ.
PS: she has a Nikon Inline scope with 5" eye-relief because it's a great scope and we both like her eyebrows just the way they are!
Here she is, a split-second after firing her 375. Note the large gap between the scope and her forehead.
As for the gun, here is a great load with a 100 yard target