Compare the bc and speed of the 400 grain bullet that you presently use to the lighter bullet that you are considering. Make your decision, if the trajectory and windage is beneficial to you.Every chance I get!
But, seriously, despite the change in view, I am not sure whether I should use the lighter bullet, or get stick with the standard 400 gr. I keep waffling on how much of an advantage it is.
Seems simple to adjust the sight-in to your 400 grain before leaving for a buffalo trip. Either way, make the choice to satisfy your situation.