If you just want practicality and availability, ie... a gun that will put heavy game on the ground fast. I would go with the Ruger or Remington. I have a M77 hawkeye African with the blued steel and walnut stock. A CRF Rifle for under $2000 including a great scope it is all you would need. I can load mine with a 340 grain Woodleigh to around 2525fps, or a 400 grain solid at 2,300 fps. It will drop anything that walks and do it at lower pressure and shorter action than the .416 Remington Mag. The action length doesn't bother me but the pressure thing does, mainly because I don't like straining the action on my rifle if I can help it.
Now if you want game stopping power AND nostalgia and romance, you can't beat the Jeffrey. It was the working man's rifle of an era that is now long gone. The .416 Rigby also has quite the pedigree but it is the Ferrari of the mid 40's. It was a wealthy man's medium-large bore. Either of those could be had for under $3000 with a scope if you look around. The downside is that brass alone is more than twice the price of the Remington and the rigby and both of these burn an average of 20% more powder. People might say "well you don't need to constantly be shooting full power loads out of them." To that I would say, "Then buy a smaller gun.
So to sum up. The Ruger/Remington is inexpensive and high quality with a whole lot of hitting power but very utilitarian and has almost zero romance
The Rigby/Jeff are oozing romance but cost a fair bit more... Don't even get me started on factory loads for these two.
If cost were not a concern, I would personally own a Jeffrey rifle made in .404 with it's bluing worn away about 5inches from the end of the barrel (by a white huntershand while over the shoulder), the wood reoiled so much that it was almost black, and the checkering worn to the point that all the little diamonds were round and shiny on top.
But I don't, so I own a .416 Ruger.