22-250 is a fine varmint round, as mentioned earlier a fast twist barrel and heavier bullets would be preferable so you don't shred the cape. The problem with 22 cal bullets is that most are designed to grenade when they hit something. On my last safari I was only hunting small animals (Oribi was the largest) I took a howa 6.5 grendel with 120gr GMX handloads and it was about perfect on Impala sized animal down to tiny ten. Larger calibers with solids work wonders on the tiny ten guys, in the 22 cal the 22 hornet is hard to beat for that use. But no matter what you use don't hit the shoulder shoot a little behind more like a whitetail shot, to keep from tearing the cape up.