There are a lot of good comments here, I think we have an amazing choice of quality bullets today. I've shot a lot of Barnes TSX and TTSX in many different calibers, my main comment would be that all of the Barnes bullets have shot well with great accuracy and grouping.
My hunting experience on dangerous game with Barnes TSX is limited but includes all one shot kills on cape buffalo and a lot less one shot kills on Australian water buffalo in .375 300gr, most animals shot close in under 100 yards, bullet performed as expected, I shot one cape buffalo at 225 yards, the recovered round had much less expansion, I assume it was due to the velocity drop.
I've shot .30 cal 150 gr TSX in .308 and felt that the bullets were too hard for medium soft skinned game (maybe little expansion), I have since moved down to .30 cal 130gn TTSX in .308, I hope to have some real use feedback on this in the next few months. I can see where users are recommending to drop down to a slightly lighter bullet and pick up speed for mid size calibers for soft skin game.
I have to say I'm still a big fan of soft point bonded bullets such as Swift A frames, Hornady DGX bonded and Nosler Partition. I've recently moved to .416 Rem for buffalo and similar, I will be shooting Barnes TSX, Federal with Swift A Frames or Hornady DGX Bonded, all 400gn ammunition. I'm very impressed with the .416 compared to the .375 and believe that any of these quality bullets will work well.
I have to comment that Barnes and Hornady have done a great job with availability over the last 5 or 6 years. I'd like to be able to comment about all the other great bullet options but I deliberately limit my bullet selection to a few as there is just such a large selection available today. Once something works well for me I try to standardize to 1 or 2 bullet options for each hunting caliber.
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