My wife has accompanyed me on three of my four safaris. The first time, a 24day hunt in the Deka Safari Area, she went out with us quite a few days and generally had a blast. She got chased up a tree by a buffalo bull, had the wits scared out of her when a Black Rhino chased our truck down the road, with us backing in reverse, for more than a lkilometer. and did her own 5-day hunt, taking a nice kudu and 40" sable. The next time was a 15 day hunt in Charara and Matetsi, and she was along though she mostly stayed in camp as we were mainly lion hunting. She did make a couple trips to Kariba to shop and relax while we were hunting, enjoyed it a lot. On that trip, she did accompany me to within 100 yards of an elephant bull, and was good right up until I handed her my .470 and suggested she go with Roy Vincent and shoot the bull. Any hope of having an aspiring elephant hunter for a wife vanished in a split second. She couldn't give me that double back fast enough, and went back to the truck to wait while we finished up our business.
Last year, we took a family vacation to South Africa, and brought our children along with us. My wife only went out hunting one day, but did spot the Nyala that I ended up shooting. She LOVED Kruger Park and Monwana Lodge, in the Thornybush Game Reserve.
I'd take my wife along nearly every time, unless I were hunting in a rougher hunt. Any of the southern African hunts should be easy for the wife.