Yes, I suppose that could play a role.
What I do know is that bullet construction and velocity on impact play a role - i.e. a frangible bullet will have a devastating impact if it penetrates the heart , often destroying it; whereas a solid or tough bullet (like an A frame) will generally just make a clean hole , resulting in a slower kill. (The fellow from NZ who writes on terminal ballistics has done a lot of studies on this, which make interesting reading).
My observations are based on the use of tough/premium bullets as we mainly use that type for our applications.
Having said that, I did shoot a few wildebeest with Nosler partitions. The kills were spectacular, but the meat damage was too extensive for my liking - looked as though they had been shot with small grenades!