On my 2007 hunt to the Eastern and Southern Cape regions of South Africa, the only rifle that I took was my .375 RUM with 270 gr Barnes TSX handloads. This combo worked great for the bigger stuff, like Eland and Kudu, and didn't do too much damage on my Vaal Rhebok and Black Springbok, but it just about cut in half a Jackal and a couple of Steenboks. When we went to specifically hunt Cape Grysbok, I borrowed a rifle from the landowner chambered in .308 Win with 150 gr FMJ bullets. That FMJ bullet only made .30 caliber entrance and exit holes, and he made a beautiful full mount.
This past July I hunted the Limpopo Province of South Africa with my .300 Weatherby and 168 gr TTSX bullets. Since I knew that I would be hunting some small animals on this trip, I worked up a load for my .300 Wby with 150 gr Hornady FMJ bullets which shot sub-moa in my rifle. One of these FMJ bullets worked great on a African Civet, but when I squeezed the trigger on a Caracal, all that we heard was a loud CLICK. In almost 50 years of reloading (a dozen rifle and pistol calibers and over 200,000 shotshells) that was the first time that I ever had a primer go off and push the bullet into the barrel, but not ignite the powder. And that was the only cartridge in that box of 20 that did that.
Anyway, that misfire rendered my .300 Wby useless, but luckily, for the first time in his guiding career, my PH had a .22 LR in his truck and I was able to borrow it and make two 165 yd hits on that Caracal.
The other small antelope that I wanted to hunt on that trip was a Kilpspringer. All of the Klipies that we found were extremely skiddish so I chose to use the 168 gr TTSX bullets because I had more confidence in them. I shot my Klipspringer at 314 yds and I shot him "in the middle" to reduce cape damage for a shoulder mount. I also used a 168 gr TTSX bullet to make a 290 yd shot on an old male Baboon sitting in the top of a tree . The TTSX bullet went through the top of both of his shoulders and only left a 1 1/2" exit hole.