I was obsessed with handguns for many years, with wheel guns being my favorites. I had the honor of meeting and talking to Skeeter Skelton, Bill Jordan and Elmer Keith when I was a kid and that just helped put my passion for handguns in overdrive at a very young age.
In my experiences with wheel guns, most will eventually "shoot loose" via lots of shooting of full power loads. Fortunately, most people will never shoot one enough to know. I have put thousands upon thousands of rounds through revolvers. Some of my favorites being S&W Models 13, 19, 24, 27, 28, 29 and 625, Colt's SAA and Ruger 3 screw Blackhawks. If I recall correctly, Elmer Keith only fired 600 or so rounds his first year with the M29. When I was shooting handguns regularly, I would put 500+ rounds through one (or more) of my revolvers in a weekend.
I have sent S&W Models 13, 19 and 29 and a few Ruger Old Models back for rebuild. That was after shooting a LOT of ammo. I mostly burned Unique and 2400 pushing Keith profile cast bullets. I never "shot loose" any S&W Models 24, 27, 28 or 625. I considered a revolver "shot loose" when it was out of timing or begins to malfunction. My favorite 4" M29-1 was rebuilt 3 times.
I will never shoot like that again in my life, so the revolvers I currently carry will never be put to those extremes.
Of all the revolvers I have ever owned, my favorite ones to carry will always be S&W M29 4', Colt's SAA .45 colt 4 5/8", and a Ruger Old Model 4 5/8" .357 that Jim Stroh converted to .44 special for me (thank you, Skeeter) and of course, S&W M19 4" such as was listed and sold here. It is one of the best of the best. No need to pound them to submission with full power loads. The gun and your hands will appreciate it.
Safe shooting