The 300 grain TSX is a popular bullet for the 375 rounds for dangerous game, plenty have used them here if you do a little looking. The ammo is all up to whether it shoots well out of your rifle.
I have not used that particular ammo, but used Barnes Vortex with 300 Grs TSX bullets, and they performed great on animals from Warthog, female Cape Buff to a Lioness. My rifle CZ-550 loved the Barnes Vortex ammo.
Hello. I see you hunted with Sampie recently. If you don't mind me asking, where did you hunt with him? Zim or SA? And was it with a bow? What did you hunt?
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