What??? No mention of 45-70???
BTB PDJ 425 gr and 525 gr PD at about 1600 fps are perfect medicine for critters with fangs and claws.
When I started looking, the 45-70 was a definite contender. I've used one on bear before and it was quite effective. These days, my taste runs towards the more obscure or less used cartridges. When I stumbled on these two rifles, both seemed to fit the bill. The 375 shoots a 255 grain bullet at ~1800 fps. I can get around 2400 with a 250 grain bullet in the .358. Both are more than adequate for deer and bear, and I wouldn't be afraid to tackle anything in North America with the 358 and a good bullet. My bear trip is off, but the 358 will be accompanying my 8mm Rem Mag on a trip for zebra and giraffe in September. I've found a load with the Speer grand slams that shoots well. (Initial groups were poor, but a little more powder and longer OAL tightened things up) I'll be using these, with Swift A Frames in the 8mm.