Jumping in here far after this useful thread got going, I've hunted a lot with traditional ML in U.S. and some in Africa (impala, waterbuck, nyala, gemsbok, and kudu), and know others who have, as well.
A big, slow-moving slug of the past has killed a lot of game all over the world, and the old adage to get as close as you can, and then shoot a gun you know well and can shoot accurately without flinching, thus putting the first bullet in the right place, has a great deal of merit.
So often we hear from colleaguese and especially PHs how modern shooters arrive with their expensive, super-powerful, behemoth modern magnums and Nitros, having shot it only a few times (or not at all!) due to fierce recoil and result trigger jerking. Can't hit the side of a barn with it, and max range is maybe 40-50 meters - from the P.H. point of view.
Yes, 2100 fps or so is the mantra velocity for big bore performance on large and dangerous game. But only the stoutest modern smokeless MLs are going to get there, and they tend to shoot quite lightweight bullets compared to many traditional ones. But again, many a traditional ML already has a bullet diameter of an expanded and less intimidating .375 H&H or perhaps a stouter .416, and a lot of mass in its bullet.
Yep, pure lead isn't so good for big game, and 1:20 tin to lead alloy helps a good bit for penetratation, whereas the old time BPE cartridge bullets were around1:12 alloy or possibly 1:10. Old Winchester bullets, BTW, were 1:16 alloy.
I think most people who want to hunt Africa with a ML already have their act pretty well together and just want to find a suitable loading there (powder plus caps or primers) to pretty well duplicate what they are used to.
Now as a newbie here I don't know if Blackhorn 209 powder is available in Africa, but oh my - in my opinion it's worth every penny. Created in the first place to have the pressure curve of BP, and with the power and low fouling of BP's finest form in the past.
Aloha, Ka'imiloa