I enjoy obtaining rifles chambered for many, various cartridges.
I am a contrarian, to those who want to "downscale" to just a few chamberings.
The ammo shortages of a few years ago taught me the folly of having only a few chamberings.
There have been at least two times in the last 15 years, where only the most obscure factory cartridges where available.
I think I've learned my lesson now, and have enough ammo to get through a shortage, but you never know...
When the "big box" stores have run out of .223 Remington (5.56x45), .308 Winchester (7.62x51), .243 Winchester, .30/06 Springfield, etc., the "mom & pop" stores still have a few old boxes of .222 Remington, .22 Hornet, .303 British, .30-40 Krag, .300 H&H, and almost any Weatherby ammo you would want.
Diversity is the "spice of life!"
(at least, when it comes to cartridges)