I have to agree with Huntingbigun; When it comes to hunting, I want as big a blood trail (if the critter doesn't go right down) as I can get, and I prefer TWO holes spurting blood over one.....I want a bullet that will go in, expend it's energy, and pass through......two lungs that are out of commission and not oxygenating (but leaking) blood are better than one. I think you would hate yourself if you tried to take a larger critter such as wildebeest or zebra with this load and lost it......hell, people loose those critters to good hits with heavier, larger bullets.........why take a chance?
Also, don't forget that if your shooting lighter bullets at longer ranges, the wind will have more of an effect on the bullet.......maybe causing a miss or (worse) a gut shot animal.
Again..............why take a chance when paying so much for a safari?
But to answer your question: I don't think I would take anything bigger than a impala/reedbuck/baboon with such a load..............but that's just MHO.