Bullet performance, bullet construction, caliber, velocity, BC, barrel length, CRF vs PF and the intricacies of reloading are fodder for on-line forums but in the real world most hunters/shooters don't care. They buy off the rack rifles in common calibers and feed them whatever ammo is on the shelf. Then they go out and kill a lot of deer, moose, antelope, bear, coyotes and other game.
The major gun manufacturers and major ammo producers happen to know a little bit about what they're doing. Most of them have been in business for over a century. They know how to build capable and functional rifles and they know how to manufacture quality effective ammo. All the circular debates we have about rifles and ammo is interesting but it's largely academic. Whatever differences MIGHT exist between premium rifles/ammo and ordinary rifles/ammo has almost no influence on whether or not meat gets put on the table. Shot placement and the vagaries of each animal's constitution are both way more important than bullet construction. If you put a bullet through the heart/lungs or brain it will die and the caliber, velocity and bullet construction are only minimally important.
Since we are on the topic though I might as well add my two cents to this circular debate. IMO the quest for maximum velocity has outpaced (pun intended) the bullet manufacturer's ability to keep up. Bullets designed to operate at normal velocities will fail at high speed and bullets designed to operate at high velocities will not work as advertised at less than optimum speed. As a reloader almost every bullet I buy has a recommended velocity range because bullet construction has gotten so specialized most of them only work as advertised under controlled circumstances. The idea of a general all purpose bullet is becoming an anachronism.
AH is a small subset of hunting overall. The game we pursue (or in my case hope to pursue) and the guns we use are different from most of the hunting world. We talk about 40 caliber rifles, monolithic bullets and dangerous game. In the real world a 300WinMag is a monster caliber that most hunters think is overkill. They use 243, 30-30, 270, 308 and 30-06 rifles and buy their ammo at Walmart or Cabelas. Because of that Remington CoreLokt and similar ammo has killed and will continue to kill more game than all the premium ammo and reloaded ammo combined. They couldn't care less about +/-100fps of muzzle velocity or whether or not they recover the bullet. All they want is meat and maybe a rack big enough for a little bragging rights. Whether or not the bullet separated is completely beside the point.
Even though I hope to hunt Africa someday and even though I own some pretty cool rifles in some pretty cool calibers I'm basically a venison hunter. I don't agonize over velocity, bullet construction, or bullet recovery. Meat on the ground is the goal and as long as that happens neither me or the animal cares whether the bullet retained 99% of it's mass. Dead is dead.
I almost forget, I've never had a CoreLokt bullet fail. Whatever that means. The game died every single time.
YMMV