agreed, only vital hits count. i disagree a bit about a larger gun not making a difference tho, if that was the case, you would be using a 9mm
In fact, until I got the .45 super, I carried a 9mm. I didn't say it wasn't more effective, I just said the difference was going to be marginal and you would never be able to chock up a kill to those additional foot pounds. A 9mm will still kill a bear, but I can fire the .45 Super almost as fast. It is about finding efficiency for me. 9mm is lethal but won't break big bone well due to the lack of mass. .45 Super will and I can fire it almost as fast. A .44, .454 etc. produce slightly more dramatic wounding maybe if a bone is hit, but I would bet, short of hitting a bone, one would have a very hard time distinguishing the difference between a .45 Auto/Super/Rowland wound track from a WFN hard cast, and a .454 Casull shooting the same type of bullet, despite the fact that the .454 will be carry well over twice the energy.
Now I will concede that the difference is more stark when comparing JHP ammunition. This would be for a strictly hunting application where you can pick your shot. The big magnums start to shine here as they can penetrate AND expand, but I wouldn't recommend a JHP for follow up unless it was a smallish bear, Hard Cast WFN is the ticket here IMO. I would want my round to plow straight through anything in its way to hit what I originally pointed it at. I am in no way condemning guys who can shoot a big handgun straight and fast. I just can't. That is the reason I am using the biggest handgun I can shoot well with speed. I also don't have the time or money to re-learn to shoot a big handgun in double action. So I stick to what I am used to in a platform that works.
A lot of guys I know will carry the biggest handgun with the impression that they just need one hit, or that just because they have a .44 mag, they will come out on top. These are the guys who carry it to try and prove some "machisimo" or something and are never going to be practically in a situation where they would need to use it. Practically, I would rather have a smaller handgun and swallow some of my "machisimo" pride, than get myself hurt because I wanted to carry my hand cannon. A lot of those guys I see at the LGS also don't hunt bears as prodigiously (or ever) as I do in the Adirondacks. They carry their guns while hiking on a well traveled route that bears are never seen near, just so they can be seen as the potential "hero" should something go down. My handgun is a hunting accessory for a particular instance which isn't unrealistic or improbable, a wounded bear that has laid down in thick, thorny brush. I don't even carry it in a holster when I am hunting because I don't need it when I'm actively hunting, I have a rifle. It is in my pack for follow up and comes out when I start to track a hit bear.
Theirs is a show piece with little practical thought going in to it. This is also the reason why I don't usually talk to people other than sales people at my local shooter's supply. I get tired of "advice" from guys who don't know what they're talking about, have formed a set-in-stone opinion, and have no experience to back it up (talking about the "gun shop lurker", not anyone on AH.)