I have not used it in Africa, but I've used it on US big game, as it was the only 416 Rem load I could locate at the time (my personal preference is for the Swift A-Frame). The fusion 400 grain performed very well on nilgai on two instances. The bullets mushroomed perfectly, both times dropping in its tracks an animal that often is very difficult to put down with one shot. I hesitate to make sweeping conclusions based on two instances, but I had no complaints regarding the Fusion ammunition.