My favorite rifle is a 7mm Rem Mag my dad gave me as a gift, Interarms action, beautiful walnut stock, and made just to my arm-cheek-etc measurements...I've killed 90% of my big game trophies with it. (Not approximately; literally 90%, 18 out of 20...just not counting pigs and peccari).
But my best rifle is a 338 win mag, made by David Miller...but I really doubt that rifle will see field action any time soon, more of a collection rifle, it shoots awesome but just to damn pretty of a gun to be wailing around in the field...and a shame to! But may be someday!
My dads favorite rifle was a 375 H&H, he did A LOT more hunting than I have done, easily took a couple of hundred of animals, and many of them with that rifle, a wedding gift from my grandpa to him, and oddly one of the plainest rifles in his collection, this 375 H&H is a good old out of the box Winchester Model 70 with may be a couple of minor modifications, this rifle took an amazing array of animals, from the north west territories to Zimbabwe, and from Siberia to South Texas, when you see that rifle it tells you stories, it's amazing just a battered old Winchester 70, but man did he love it!!! And those are the ones that count! Right?