Nosler 300 gr. partitions were my goto load for getting up cloase and personal with bears in Alaska. Can't say about how they will work in Africa yet but I can say they saved my tail up north more than once. I mostly used handloads at about 2500 fps, however, there are
plenty of both factory and specailty ammo companies out there to pick from: Federal, Hornady, Speer, Remington, Winchester, Nosler
all now load or have loaded in the past some excellent 375 ammo, ( I have a stash of 300 gr. failsafe's put back). There are also several good specialty ammo companies with loads that will work : Double Tap, Longhunter Custom Ammo, etc. I have used some 235 grn. Triple Shocks from Double Tap that were very accurate in my 375 Encore, (they were also loaded to the max.) Used some 260 gr.
Accubonds from Longhunter- also very accurate with very managable recoil. I really like the 260 gr. Accubond for all around use on
on game in North America. i don't see any reason it wouldn't work well in Africa on non dangerous game. The Accubond load from
Longhunter gave me some of my best groups in my old Interarms Mark X.