Practice and be prepared to shoot at 50 to 100 yards. It is likely that you will not experience what you dream of, at least I didn't! And it was better...I wasn't scheduled to hunt buffalo but was open to the opportunity, but my PH said is an "exceptional old bull past his prime and pushed out of the herd" in the Waterberg Mountains.
After an all day stalk, chase, push, seeing him disappear at 30 yards through the brush and then (unknowingly) this old Dagga Boy circled back and followed us through the thick bushveld (it rained a week earlier), fresh dung and tracks where we'd previously stalked, until finally at the end of the day he just appeared! He was briefly looking the other direction. I had just enough time to get on the sticks, line up a shot (slightly quartering towards me), safety off and let one go. As soon as the safety was off he turned to see us! Not the shot I expected; higher on the shoulder and hit him in the spine because he went right down! It happened so fast that my camera guy could not get the video rolling! A soon as he was down we ran up and at I put two more in his heart because he was stunned and still moving... Very exciting. You would not believe the excitement everyone had - Two PH, two trackers, film guy and me were all thrilled and celebrating.
.375 H&H Sako Finnbear with a Leoupold 1-6, using 350 Grain Barnes TSX which I hand loaded. At this point I had already taken a Giraffe with a great neck shot at 40 yards and he went straight down as well as a Sable in thick brush at 70 yards with a clean shot behind the shoulder, so I was confident the rifle would shoot well... I believe I use 100 yard zero and practiced at various distances.