Hi Marsksman, yes the 601 action is overbuilt for a standard 222, 222 Rem magnum would be better suited but ammo not so easy to find at least in europe. Though it makes a great combination nonetheless.
About being able to swap barrels it may not be so easy as they are screwed in to receiver real tight.
I had one ZKK600 barrel removed from receiver, professionally done by a machinist in his workshop and it needed tightly securing the barrel without damaging it, fitting brass shims to receiver before tightening it with a special tool with 2 bolts and nuts on each side and then using a long steel lever arm tube to unscrew it, heating it lightly with a torch in the process for expansion. Think about headspace too. It would be quite a job each time to swap them. I would go for a change of caliber with one barrel fitted permanently.
I have left one ZKK600 in 30-06, three in 7x64, two in 8x57S all made in 1967 with peep sight. Also two ZG47's one rebarrelled by Hammerli in Switzerland in 6,5x57 and one original in 8x60S. And a few rimfires.
I don't hunt but shoot at the range at 100 meters here in Slovenia. In Switzerland had a corridor at the range for 150 meters and that was optimal, got good groupings also with peep sight. All my best from Europe