You can get by on most African plains game with 270Gr bullets, except for eland & giraffe. For those, you will benefit from employing the 300Gr bullet. I personally employ the 300Gr bullet for everything and simply have my rifle zeroed in for it’s maximum point blank range with the 300Gr bullet. The reason why many of us old timers exclusively prefer to employ the 300Gr bullet, is because we typically like our soft points & our solids to have matching weights so that we don’t need to keep sighting in the rifle for different load weights. And most .375 Holland & Holland Magnum solids (especially factory loads) are of 300Gr weight.
BRNO ZKK602s were known as the “Workhorse Of Africa” when I first began hunting in Africa during the 1970s. Back in those days, the BRNO ZKK602 and the Interarms Whitworth African were the only commercially manufactured control round feed rifles to be offered in dangerous game calibers (namely the .375 Holland & Holland Magnum and the .458 Winchester Magnum). And due to the international arms & ammunition embargoes that were in place against South Africa & Rhodesia at the time, just about all the newly imported firearms which one could see in Africa back in those days… were Czech BRNOs. Virtually every white hunter back in those days, used to keep a pair of BRNO ZKK602 rifles in camp (one in .375 Holland & Holland Magnum and one in .458 Winchester Magnum).
I still personally consider the BRNO ZKK602 to be one of the world’s finest .375 Holland & Holland Magnum rifles ever to be commercially manufactured. It’s a real pity that they ceased production in 1993. I’ve employed quite a few of them over the years. The pre 1974 ones with the neat little pop up peep sight in the receiver, were the most well finished.
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The most accurate cartridges which I’ve ever fired from them, are the 300Gr Norma Oryx and the Norma 300Gr round nosed Barnes Banded Solid. They’re pretty forgiving regarding what bullets they like. Although, I’ve seen one specimen which didn’t like the flat nosed Hornady DGS (Dangerous Game Solid) cartridges. Feeding was sticky until a gunsmith in Bloemfontein had the feeding ramps smoothed out with a file.