Regards the actual topic of the thread...
I guess what put me on the path was probably a 50 Alaskan in a Marlin lever gun. I tried it at a shooting school and while I wasn't ready for that at the time, I was intrigued. I took a brief detour to a handgun: a Blackhawk 45 Colt 5 1/2 inch barrel. Loaded with Buffalo Bore 325g bullets at about 1300 FPS it is a vicious little beast. That was at another shooting school and I actually borrowed a 500 S&W so I could have something comfortable and easy to shoot for the majority of the class and then shot an elk with my revolver and I liked what it did.
Got a 50BMG M82a1 in honor of Obamas 2008 election and avoid the ban that never came. Sure, it is $5 or more a shot, but 10 shots is a completely satisfying day of shooting, so it is kind of a cost savings if you can manage to have the sun right in your wife's eyes when you try to actually say that. But the part about it being satisfying in small doses is completely true.
That brought me to my 404 and I'm starting to really enjoy it. Had it out the other day and when I came in my wife commented that she heard it quite clearly from in the house but that it really did have a nice deep boom, like a Harley rather than a rice rocket. If she finds the sound of the 404 more pleasant than a 30-06, I suppose I'll just have to be the good husband she deserves.