I've had three Vortex optics go sideways on me, two red dots and one set of binos. Those experiences have influenced my purchases moving forward, so let's just say I'm not a fan.
The LPVO reticle (in general) is built around the concept that it will be used on the AR or similar platform...meaning calibers ranging from 5.56NATO to 308WIN. Most of them incorporating some type of BDC reticle based on barrel length, bullet weight and bullet speed. I'll go out on a limb here and say there aren't a lot of AR's chambered in 375H&H and even fewer LPVO's calibrated for them.
Will it work, absolutely. I'm sure it will be more than capable of handling the recoil and it could easily be mounted in QD rings as well. The point I'm making is that there are much better options available that are better suited to your application.
For a DG capable rifle I would want an uncluttered illuminated reticle with true 1x at low power and at least 6x at high set in QD rings. The Leupold VX-6 HD 1-6x24 or the AccuPoint 1-6x24 would be a good places to start IMO.
If money is tight, I get it. Use the LPVO until you can get what you really want.