I always prefer lead cored bullet designs whereever legal or whenever I can get them. But I can readily vouch that the 300Gr Barnes TSX (fired from a .375 Holland & Holland Magnum) is magnificent medicine for hunting hippopotamus bulls on land.
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Before employing the Barnes TSX on my two most recent hippopotamus hunts, I always exclusively preferred solid bullets for hunting hippopotamus on land. Because nothing tests bullet penetration & structural integrity the way a body shot on a full grown hippopotamus bull can (aside from frontal brain shots on bull elephants).
Now, that said… I’d personally avoid employing them for hunting the great cats (esp. a broadside heart-lung shot on a lion or leopard that is shot over bait unless if your point of aim happens to be the shoulder bone/scapula itself). I’d also avoid them in slower calibers such as the .470 Nitro Express or .500 Nitro Express or the .577 Nitro Express or in the .458 Winchester Magnum (unless you employ a bullet weighing no heavier than 450Gr in the latter). In the slower caliber, they do (now & then) fail to expand properly & simply bore clean through like a solid.
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This 570Gr Barnes TSX (for instance) was fired from a .500 Nitro Express Federal Premium Cape Shok factory load into a Cape buffalo’s heart-lung region from a broadside position behind the shoulder. It incurred absolutely zero expansion whatsoever.
My good friend white hunter Mark Sullivan has had expansion issues with the .585 Barnes TSX (being fired out of his .577 Nitro Express Heym Model 88B) on at least three separate occasions till now.
So my recommendation is to only employ the Barnes TSX in high velocity calibers (such as .375 Holland & Holland Magnum, .378 Weatherby Magnum, .404 Jeffery, .416 Rigby, .416 Remington Magnum, .458 Lott, .450 Rigby Magnum, .460 Weatherby Magnum, .500 Jeffery).