I have hunted Africa a bit and quite of bit of that with the R8 - to include a bit of dangerous game. I also own more than a couple Mauser based rifles. I am totally comfortable with the R8 and find it in many ways superior to my Mausers, Ergonomics are perfect, second shot is the quickest of any legal repeater, and I don't own a rifle with a better trigger. And what "fair set of issues" has it had - exactly? The R93 allegedly had problems, but the R8 seems very robust indeed. My own sampling is admittedly limited. But in addition to myself, I know at least half a dozen folks who hunt the R8 regularly worldwide. They are all experienced with a wide range of makers and actions, and they hunt the R8 because they believe it is a superior rifle. Also, one of the most abused observations about Germanic firearms is their "over engineering". Frankly, that is a crock. I own Teutonic SxS's, OU's, drillings, Bockbuchsflinte, and double rifles (to include a Baser S2) - they all function flawlessly. Just as good as any British rifle or gun with which they share the gun room. Just saying.
The cocking mechanism is just as fast as any other rifle I own. Like most things, it just takes a bit of practice. It is essentially the same as used on the K-Gun and it works there as well. It is also the safest mechanism in the field today short of an empty chamber. No knock on the 98 and its ilk, but I have hunted Africa with both, and the R8 has become my favorite firearm over its "less advanced" predecessors.