ABSOLUTELY Phil!
The bottom line is that the bullets must leave the barrels at the exact time the barrels are pointing, one a a time, exactly at the point you intend to hit (drop being compensated for by the height of your front sight).
So, theoretically, there are any numbers of bullets and powders than will shoot perfectly well with your rifle the way it is assembled, i.e. without requiring re-regulation. The secret, as you have found out, is to go through a process of trials and errors so that the combination of powder type (i.e. burn rate); powder quantity (i.e. velocity); primer (i.e. ignition rate); bullet weight (i.e. inertia to overcome and momentum required); bullet bearing surface (i.e. resistance to propulsion) + if you really want a laundry list: bullet material; external temperature; your own shooting style; etc. etc. not to forget the alignment of the planets LOL, all end up producing that magic moment when the bullets exit the barrels at exactly the right time when the barrels are at exactly the right spot in their recoil.
A number of folks have developed an array of loads for their doubles, especially folks who shoot a .450 of one persuasion or another and who can select from the entire range of .458 slugs, that allow them to use their rifle from elephant at max power, down to driven wild board with "half" bullet weight and "half" powder charge (beware: one needs to use a filler for the rest of the case space in such case).
Not only you "should" but you "will". Just a question of trying all possible permutations. Hint: once you have the magic recipe, write it down