Hi WildRose
Firstly, the definition of a "gun nut" is when you have more rifles than you can shoot in one calendar year (a rifle a day keeps the insaneness away!)
Hunting in Africa, bring the .375 and 300WM (it is just more fun shooting with 2 rifles than one). I normally travel with an additional scope, but when taking 2 rifles I don't (most of my rifles have the same scope, mounts, rings and are easy inter changeable. I also take normally 2 of the same make/brand, eg. 375 H&H and .308Win in CZ 550, thus same scope mounts and both have 4-12 x 50 Zeiss Duralyt). One thing to consider if you are flying in a small aircraft to and from your final destination, luggage does become a problem, a large 2 gun airline gun case with trolley wheels don't fit in the small luggage compartment or on the back seat of the plane, a pair of small soft gun bags will do better.
As for the Buff, shoot with normal 4 x magnification, if closer shots are required, remove the scope and shoot with open sights. You will either shoot the buff at 40m plus or anything closer the open sights will do just fine (use red fiber optic in front bead or green if you prefer...)
Good luck and hoping to hear your success story and see the pictures of your successful African safari.
PS: Don't forget to practice shooting with open sights, the rifle sits slightly different in your hands than with a scope.