Hi Sgt_Zim,
If you are interested in a little more velocity and can stomach the loss of 36gr bullet weight, it might be worth considering a 250gr Nosler Accubond.
250 gr Accubond
SD: 0.267, BC: 0.494
286gr Norma Oryx
SD: 0.305, BC:0.330
Nosler gives the Accubond an MV of 2525 with 56.5gr of Varget which I find a little more believable than some of the other claims you see written. (Norma factory ammo isn't usually rated as that slow snf 285gr oryx has an MV of 2362 according to their website).
On paper, the drop difference when zeroed at 200yds for a 300yd shot is a bit over 3" but I'd be tempted to say that the Accubond will shoot flatter with less effort and envelope pushing
What is your intended quarry species?
Scrummy
As it happens, Midway had NAB 250 gr on clearance a couple weeks ago and I bought a couple boxes.
For the foreseeable future, I'll be hunting oinks with it . IMO, they make good practice for requiring rapid follow-ons if you want to get more than one of them from the sounder.
I've also got some NP286. TBH, I don't expect a great deal of difference between any of the 286s.
I also picked up some Big Game at the same time. Western Powders sez I should be able to get 2600+ fps out of the 250s. I'm not holding my breath on that number.\
I was looking at some 375 H&H stuff for a friend in several of my books, and it occurred to me that without some fairly compressed loads, esp. on the Nosler bullets, 375H&H 300 gr velocities are upper 2200s to mid-2500s. Those look an awful lot like 9.3x62 velocities with 286 gr bullets.
I'm trying to finagle a moose hunt up near Holy Cross, AK for either next summer or the summer after. 250gr AB is more than enough pill for moose, and I should think it would be enough for any grizzlies that develop too keen an interest in my buddy or me.
I had tried Varget with the Hornady 286, but they seat so deep, I couldn't get but about 55 or 55.5 grains into the Norma brass without it turning into a compressed load. As it is, I'm north of 2400 fps with those bullets and 62gr 2000-MR.