Have both, I'm grabbing my 458Lott for Buffalo, Elephant, and land Hippo (I don't think a Rino is in the cards anytime soon). Anything that requires a precision shot, I'm grabbing my 375h&h. The 416 is a bridge between the two. They will all kill, it just depends on what you are after. If you want the one rifle safari, take a 375h&h and don't look back. If you want to put the time and money into learn how to shoot a 458Lott. It is very doable.
The 416 Rem does run at higher psi so has been an issue. If shooting handloads that can be addressed.
Probably about the same time the 458win mag had issues.When is the last time they have had pressure issues? With modern powder I have not seen it. In the summer here in South Texas it has been 100+ very high humidity and I have never experienced issues with my 416REM shooting Federal, Barnes, or Remington ammunition.
A precisely placed first shot and a large caliber rifle are not mutually exclusive.... A precisely placed first shot negates the need for the bigger rifle later.
Makes sense to me.
That's like asking if you like chevy or ford, or blondes or brunettes. People have their preferences, both will get the job done if you put it where you're aiming. I have both and like both. Wouldn't hesitate to shoot anything with either. I guess if you're talking the biggest and baddest DG, and given I have both in the safe, give me the lott for the bigger punch. But I wouldn't feel under-gunned with a 416.