Your question is a little vague. You say a .375 factory round but you didn't say what the factory round specifically is, other than .375. If it's a .375H&H round then you should certainly be able to shoot it in a weapon chambered for the same, but I'm sure you knew that. If the factory round is something other than .375H&H, DO NOT put it in your .375H&H.
There are a few rifles calibers out there designed to handle rounds in multiple chamberings. For example I know you can fire a .458 Win Mag round in a rifle chambered for .458 Lott. That said I wouldn't put a .375RUM or .378 Weatherby in a .375H&H chamber. I don't think it could be done even if you tried. The .375H&H case tapers from wider to narrower from the rim to the neck, part of why it extracts so nicely. The RUM and Weatherby versions do not have this tapered design. Furthermore the RUM and Wby cases are wider overall than the widest point on the H&H case.
Again, with the info you provided my advice is DO NOT do this.
..all factory rounds are fired only once. If it's a .375 Holland and Holland factory round, then fire away. Anything else would be, methinks, rather reckless..
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Made it to Augusta Georgia yesterday for a meeting, hunt bookings are looking good for 2026 and 2027, had a great time on our Alabama safari shot a rutting deer at 200 yards with 7mm PRC near Huntsville and then headed on to Butler Alabama and semi guided my first deer ever shot a very nice broken off 8 point with hunter there and spend a few days on 1100 acres hunting preserve awesome place!
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