I have both. I would pick the 416 version for a dedicated dangerous game rifle. I believe with equal designed bullets, similar weight class per caliber; the 416 impacts harder and breaks / busts bone better. Trajectory differences for 200 yards and under are very insignificant in my opinion.I am debating between the 375 and 416 ruger cartridge. Either one will be in a ruger Alaskan rifle that I will do a stock upgrade one. Whichever I choose will be paired with a 7mm PRC. The use case for the big bore will be to Hunt Cape buffalo, American Bison and maybe coastal brown bear in Alaska or simply take with me on other hunts there as a just in case gun. I am aware that both of these maybe harder to find ammo for outside of the US but I am leaning towards them for their performance in shorter barrels and standard length actions as well as firearm availability.
I have never hunted dangerous game before so these cartridges are new to me, clearly the 416 has more foot pounds of energy I was just wondering if some of you with more experience would share your pros and cons for each caliber and explain why you would choose either.
The choice between the two, would not change my lower visibility moose-hunting habits in Alaska. But, I would pick the 416 in a forewarned, potentially hostile encounter with paws & claws. I will say, the past several years, I have carried the 416 predominately.