My Powder choice is an open question at this time. I started with some bullet testing using factory loads to see if it shoots 300g A-Frames or Barnes TSX the best for the expanders and North Fork cup point or Woodleigh Hydros for the solids the best. It is a process since I kept changing the scopes also. As of today, it seems to shoot the Barnes and Swift bullets equally well but does not feed the North Fork bullets reliably. The rifle feeds the Woodleighs flawlessly. Therefore, I plan to use A-Frames and/or TSX for DG and PG and Woodleigh Hydros only for DG followup shots. Final choice for DG first shots is going to come down to which of the two are most accurate as I believe they are both up to the task as well as which of the two shoot most like my Woodleigh solids. At least for me, I like to have a high degree of confidence in my accuracy and precision before I pull the trigger on my game tgt. It help my overall confidence when hunting. I probably put too much time into this sort of prep but it is part of the fun of planning any hunting trip and I have been milking that for all it is worth.
I have a bunch of the Barnes ready for the plains game and will use those mostly for plains game. As for powder? I am looking at R15 and Varget as two most likely options but have not loaded these larger cartridges in the past. My past experience reloading was never larger than a 308. For the 375, I am hoping to keep it in the 2500 to 2550 fps range as long as the pressure stays in the green zone. Plan to stick with Fed215 primers.