Seen folks doing some amazing stuff with 250grn Barnes TSX's from their 375's but I stick to 300Grn (TSX as well) - have a Leupold FX3 6x42 LR on it and I know my drop up to 300 yards and my load aligns to the "dots" provided in the LR reticle for 200 & 300 yards respectively. Guess this is a case of what works for you, I have had my 375 H&H for years and know it better than any other rifle in the safe to the extent that it is an extension of my arm. Irrespective it is a great PG calibre