Guys THANK YOU THANK YOU THANK YOU!!!!! I've decided I'm going with....drum roll......................................................
416 Rem Mag.
Here's why, I said before I have no interest in hunting elephant. But I do and will have Buffalo on my bucket list. I'm only 43 years old and I'm quite certain I'll be staring down black death at some point. I also may want to hunt some problem hippos in the future. My hunt next year is for a lioness so I'll certainly be back for a male lion at some point also. Who knows by then I may have the elephant itch. The cost of the ammo won't be a problem. I'll shoot the gun but like someone said I'll practice off sticks with something else. Ammo cost won't be that much of a big deal. I know the 375 is capable for all but if Im going to shoot a lion or buffalo I want to drop a hammer on them.
I've narrowed it down to a CZ 416, Kimber Caprivi or I may be getting a SWEET deal on a Cooper 416 without all the crazy fancy options but its still a beauty with a great price
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As for the 375 again on my dream list is coastal brown bear in Alaska and crocodile so I'll have 2 good excuses for my wife as to why I'll have to purchase a 375 later down the road. I've personally had someone tell me they shot at a crocodile laying prone with a 416 they wished they had used a 375. The 416 laying down, the recoil was brutal.
Again guys thanks for all the replies, when I get her and get her scoped I'll post some pictures!